Is it lifted ? You may need to tilt the rear diff to correct the unwanted angle .... the rear diff must be within 4 deg of the tranny angle so the drive shaft wont bind N blow your U joints apart.
You may check your rear trans mount N motor mounts for vibration..
Both of my vans have a 2 pc drive shaft. One has been off roadin for decades, the other can take out Mustangs on the street... with 2 pc...... you have other issues other than the 2 pc drive shaft.